| Date | Location | Result | |
| Dec 11, 2021 | Fargo, ND | North Dakota State 27, ETSU 3 | Box score |
| Dec 04, 2021 | Johnson City, Tenn. | ETSU 32, Kennesaw St. 31 | Box score |
| Nov 20, 2021 | Chapel Hill, NC | North Carolina 34, Wofford 14 | Box score |
| Nov 20, 2021 | Lexington, Va. | Western Carolina 52, VMI 24 | Box score |
| Nov 20, 2021 | Chattanooga, Tenness | The Citadel 24, Chattanooga 21 | Box score |
| Nov 20, 2021 | Birmingham, Ala. | Furman 41, Samford 34 | Box score |
| Nov 20, 2021 | Johnson City, Tenn | ETSU 38, Mercer 35 | Box score |
| Nov 13, 2021 | Cullowhee, N.C. | ETSU 56, Western Carolina 35 | Box score |
| Nov 13, 2021 | Gainesville, Florida | Florida 70, Samford 52 | Box score |
| Nov 13, 2021 | Macon, Ga | Mercer 10, Chattanooga 6 | Box score |
| Nov 13, 2021 | Greenville, S.C. | Furman 37, VMI 31 | Box score |
| Nov 13, 2021 | Charleston, S.C. | The Citadel 45, Wofford 44 | Box score |
| Nov 06, 2021 | Spartanburg, South C | Chattanooga 35, Wofford 10 | Box score |
| Nov 06, 2021 | Cullowhee, North Car | Western Carolina 43, Furman 42 | Box score |
| Nov 06, 2021 | Birmingham, Ala. | Samford 35, The Citadel 14 | Box score |
| Nov 06, 2021 | Johnson City, Tenn. | ETSU 27, VMI 20 | Box score |
| Oct 30, 2021 | Spartanburg, S.C. | Western Carolina 41, Wofford 21 | Box score |
| Oct 30, 2021 | Lexington, Va. | VMI 46, Samford 45 | Box score |
| Oct 30, 2021 | Chattanooga, Tenness | Chattanooga 13, Furman 3 | Box score |
| Oct 30, 2021 | Charleston, S.C. | Mercer 34, The Citadel 7 | Box score |
| Oct 23, 2021 | Birmingham, Ala. | Chattanooga 55, Samford 13 | Box score |
| Oct 23, 2021 | Macon, Ga. | Mercer 45, Wofford 14 | Box score |
| Oct 23, 2021 | Greenville, S.C. | ETSU 17, Furman 13 | Box score |
| Oct 23, 2021 | Charleston, S.C. | Western Carolina 45, The Citadel 31 | Box score |
| Oct 16, 2021 | Spartanburg, S.C. | Samford 27, Wofford 24 | Box score |
| Oct 16, 2021 | Chattanooga, Tenness | Chattanooga 21, ETSU 16 | Box score |
| Oct 16, 2021 | Macon, Ga. | VMI 45, Mercer 7 | Box score |
| Oct 16, 2021 | Greenville, S.C. | Furman 24, The Citadel 14 | Box score |
| Oct 09, 2021 | Spartanburg, South C | Furman 42, Wofford 20 | Box score |
| Oct 09, 2021 | Cullowhee, N.C. | Mercer 34, Western Carolina 24 | Box score |
| Oct 09, 2021 | Lexington, Va. | VMI 37, Chattanooga 34 | Box score |
| Oct 09, 2021 | Johnson City, Tenn. | ETSU 48, The Citadel 21 | Box score |
| Oct 02, 2021 | Chattanooga, Tenness | Chattanooga 45, Western Carolina 17 | Box score |
| Oct 02, 2021 | Macon, Ga. | Mercer 45, Samford 42 | Box score |
| Oct 02, 2021 | Johnson City, Tenn. | ETSU 27, Wofford 21 | Box score |
| Oct 02, 2021 | Charleston, S.C. | The Citadel 35, VMI 24 | Box score |
| Sep 25, 2021 | Boiling Springs, NC | Gardner-Webb 52, Western Carolina 34 | Box score |
| Sep 25, 2021 | Lexington, Va. | VMI 31, Wofford 23 | Box score |
| Sep 25, 2021 | Birmingham, Ala. | ETSU 55, Samford 48 | Box score |
| Sep 25, 2021 | Greenville, S.C. | Mercer 24, Furman 3 | Box score |
| Sep 18, 2021 | Spartanburg, S.C. | Kennesaw St. 31, Wofford 10 | Box score |
| Sep 18, 2021 | Cullowhee, N.C. | Samford 42, Western Carolina 37 | Box score |
| Sep 18, 2021 | Ithaca, N.Y. | VMI 31, Cornell 21 | Box score |
| Sep 18, 2021 | Lexington, Kentucky | Kentucky 28, Chattanooga 23 | Box score |
| Sep 18, 2021 | Raleigh, N.C. | NC State 45, Furman 7 | Box score |
| Sep 18, 2021 | Johnson City, Tenn. | ETSU 38, Delaware State 6 | Box score |
| Sep 18, 2021 | Charleston, S.C. | The Citadel 45, North Greenville 13 | Box score |
| Sep 11, 2021 | Norman, Okla. | Oklahoma 76, Western Carolina 0 | Box score |
| Sep 11, 2021 | Kent, Ohio | Kent State 60, VMI 10 | Box score |
| Sep 11, 2021 | Florence, Alabama | Chattanooga 20, North Ala. 0 | Box score |
| Sep 11, 2021 | Martin, Tenn. | UT Martin 33, Samford 27 | Box score |
| Sep 11, 2021 | Tuscaloosa, Ala. | Alabama 48, Mercer 14 | Box score |
| Sep 11, 2021 | Cookeville, Tenn. | Furman 26, Tennessee Tech 0 | Box score |
| Sep 11, 2021 | Johnson City, Tenn. | ETSU 45, UVA Wise 14 | Box score |
| Sep 11, 2021 | Charleston, S.C. | Charleston Southern 38, The Citadel 21 | Box score |
| Sep 04, 2021 | Elon, N.C. | Wofford 24, Elon 22 | Box score |
| Sep 04, 2021 | Cullowhee, N.C. | Eastern Kentucky 31, Western Carolina 28 | Box score |
| Sep 04, 2021 | Lexington, Va. | VMI 45, Davidson 24 | Box score |
| Sep 04, 2021 | Greenville, S.C. | Furman 29, North Carolina A&T 18 | Box score |
| Sep 04, 2021 | Nashville, Tenn. | ETSU 23, Vanderbilt 3 | Box score |
| Sep 02, 2021 | Chattanooga, Tenness | Austin Peay 30, Chattanooga 20 | Box score |
| Sep 02, 2021 | Birmingham, Ala. | Samford 52, Tennessee Tech 14 | Box score |
| Sep 02, 2021 | Macon, Ga. | Mercer 69, Point 0 | Box score |
| Sep 02, 2021 | Conway, S.C. | Coastal Carolina 52, The Citadel 14 | Box score |